Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10574482 | Journal of Inorganic Biochemistry | 2005 | 8 Pages |
Abstract
The 3-hydroxy-4-pyridinones are chelating agents of current interest due to their high affinity for hard metal ions and potential clinical applications as metal-decorporation agents. A new bis-(3-hydroxy-4-pyridinone) derivative of EDTA have been developed, and herein we describe the results of solution studies to determine the protonation constants and the partition coefficient. Biodistribution studies, performed with 67Ga-overload mice, showed rapid clearance of the radiotracer from the body, thus indicating that the new ligand should be a quite effective agent for the in vivo aluminium removal.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
M. Amélia Santos, Sofia Gama, Lurdes Gano, Etelka Farkas,