| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10574944 | Journal of Inorganic Biochemistry | 2005 | 8 Pages |
Abstract
A novel asymmetric bidentate ruthenium (II) complex, [Ru(bpy)2(PYNI)]2+ (bpy = 2,2â²-bipyridine, PYNI = 2-(2â²-pyridyl)naphthoimidazole), has been synthesized and characterized by elemental analysis, ES-MS (electrospray mass spectra) and 1H NMR. The electrochemical behaviors of this complex were studied by cyclic voltammetry. DNA interaction studies suggest that [Ru(bpy)2(PYNI)]2+ binds to calf thymus DNA (CT-DNA) in an intercalative mode. Interestingly, this new Ru(II) complex has also been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Yun-Jun Liu, Hui Chao, Li-Feng Tan, Yi-Xian Yuan, Wei Wei, Liang-Nian Ji,