| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10574947 | Journal of Inorganic Biochemistry | 2005 | 8 Pages |
Abstract
A combination of enzymatic digestion and electrospray ionisation mass spectrometry (ESI-MS) was used to characterise bifunctional adducts in which cisplatin is bound to GA base sequences in 8mer and 16mer oligonucleotides that do not contain other, higher affinity binding sites. The extent of formation of bifunctional adducts with GA base sequences was significant, but less than that seen with similar oligonucleotides containing either AG or GG sequences.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Rajesh Gupta, Jennifer L. Beck, Margaret M. Sheil, Stephen F. Ralph,