Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10575160 | Journal of Organometallic Chemistry | 2005 | 7 Pages |
Abstract
Biaryl compounds are prevalent in both nature and in active pharmaceutical ingredients. The palladium and nickel catalyzed cross-coupling of aryl Grignard reagents with aryl fluorides reported herein affords moderate to excellent yields of the corresponding unsymmetrical biaryls. In addition, the first example of a biaryl cross-coupling utilizing unactivated aryl fluorides under phosphine free palladium conditions is reported. Microwave technology allowed rapid optimization of catalyst systems, which identified several ligands for this cross-coupling reaction.
Related Topics
Physical Sciences and Engineering
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Authors
John W. Dankwardt,