| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10575597 | Journal of Organometallic Chemistry | 2005 | 7 Pages |
Abstract
Three novel flufenamates [Me2(flu)SnOSn(flu)Me2]2 (1), [Bu2(flu)SnOSn(flu)Bu2]2 (2) and [Bu2Sn(flu)2] (3) have been prepared and structurally characterized by means of vibrational and NMR (1H, 13C and 119Sn) spectroscopy. Based on spectroscopic data, dimeric tetraorganostannoxanes are proposed for 1 and 2, and monomeric hexa-coordinate structure for 3, respectively. The crystal structure of 1 was determined by X-ray crystallography. This structure is self-assembled via Ï âÂ Ï and C-H âÂ Ï stacking interactions. Flufenamic acid and flufenamates 2 and 3 were evaluated for antiproliferative activity in vitro. Among the compounds tested 2 and 3 exhibited high cytotoxic activity against the cancer cell line A549 (non-small cell lung carcinoma).
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Authors
Dimitra Kovala-Demertzi, Vaso N. Dokorou, Jerry P. Jasinski, Adam Opolski, Joanna Wiecek, Maria Zervou, Mavroudis A. Demertzis,