| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10579332 | Tetrahedron: Asymmetry | 2013 | 10 Pages |
Abstract
A concise total synthesis of emericellamides A and B, two cyclic depsipeptides exhibiting antibacterial and cytotoxic activities, is reported. A Paterson anti-aldol reaction and a hydroxy directed 1,3-anti reduction were applied for construction of the polypropionate unit with the required stereochemistry in emericellamides A and B. An FDPP mediated macrolactamization was used to construct the macrocycle of emericellamides A and B.
Related Topics
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Authors
Tapan Kumar Pradhan, Karla Mahender Reddy, Subhash Ghosh,