| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10579530 | Tetrahedron: Asymmetry | 2011 | 15 Pages |
Abstract
Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (⩾94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Rebecca E. Deasy, Maude Brossat, Thomas S. Moody, Anita R. Maguire,