| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10580352 | Tetrahedron: Asymmetry | 2006 | 5 Pages |
Abstract
A variety of enantiopure proline derived pyrrolidinium (HX)n salts have been found to catalyse the 1,4-conjugate addition of N-methylpyrrole to cyclopent-1-ene carbaldehyde with, in some cases, high diastereo- and enantioselectivity. Parameters such as water activity, choice of acidic cocatalyst (HX)n and also the amount of cocatalyst used turned out to be crucial for the diastereo- and enantioselectivity of the reaction.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Palle Breistein, Staffan Karlsson, Erik Hedenström,