| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10582704 | Bioorganic Chemistry | 2005 | 12 Pages |
Abstract
Dinuclear macrocyclic polyamine zinc(II) complexes, which have two cyclen groups linked by flexible spacers, have been synthesized as DNA cleavage agents. The structures of these new dinuclear complexes are consistent with the data obtained from elemental analysis, MS and 1H NMR spectroscopy. The catalytic activity of these dinuclear complexes on DNA cleavage was studied. The results showed that the dinuclear zinc(II) complexes can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) (Form I) under physiological conditions to produce selectively nicked DNA (Form II).
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Authors
Wei Peng, Pei-Yan Liu, Ning Jiang, Hong-Hui Lin, Guo-Lin Zhang, Yi Liu, Xiao-Qi Yu,