α-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors

A series of structural analogs of 5,6,7-trihydroxyflavone (baicalein, 1) and 6-aminoflavones were synthesized and evaluated for inhibition of rat intestinal α-glucosidase. The most potent compound, 16, uncompetitively inhibited sucrose- and maltose-hydrolyzing activities of the α-glucosidase 20 times higher than 1.