Effects of thermal, alkaline and ultrasonic treatments on scleroglucan stability and flow behavior

► Scleroglucans showed high resistance to heating (<150 °C) and different sensitivity vs. alkali. ► Triplex sensitivity was evidenced as a denaturation-based loss of pseudoplastic behavior. ► Single coil aggregates or supramolecular assemblies may account for residual pseudoplasticity. ► A different mechanistic rationale would apply for ultrasonication variable effects. ► Downstream processing-related conformational features might explain differential behavior.