Drug diffusion from disperse systems with a hydrophobically modified polysaccharide: Enhancer® vs Franz cells

► We study a new HPC modified with methyl methacrylate suitable for topic formulations. ► Systems need a determined surfactant and drug concentration to obtain cross-linking. ► Systems with relaxed structure have high drug release and diffusion values. ► Results with Enhancer Cell® are more reliable and reproducible than with Franz cell. ► Studies confirm that the new polymer makes gel structure and controls drug release.