| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10601886 | Carbohydrate Polymers | 2012 | 8 Pages |
Abstract
⺠Chondroitin sulfate formulations from shark origin are largely contaminated. ⺠Keratan sulfate comprises around 16% of these biomedical preparations. ⺠The pharmacopeiaŠmethod (electrophoresis) does not detect such contaminant. ⺠SAX-HPLC is proved to be a more reliable method. ⺠These findings forewarn manufacturers and audits for better products.
Keywords
SAXGlcAGAG(s)N-acetylgalactosamineSECGalNAcGARPHSQCPAGEGlcNAcnuclear magnetic resonanceOSCsEuropean OsteoarthrosisGlucuronic acidpolyacrylamide-gel electrophoresisSize-exclusion chromatographystrong anion exchangeNMRKeratan sulfateOversulfated chondroitin sulfatecorrelation spectroscopyN-acetylglucosamineCOSYliquid chromatographyHPLChigh-performance liquid chromatographyquality controlChondroitin sulfateGalGalactoseGlycosaminoglycanglycosaminoglycan(s)EURheteronuclear single quantum coherence
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vitor H. Pomin, Adriana A. Piquet, Mariana S. Pereira, Paulo A.S. Mourão,