| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10601951 | Carbohydrate Polymers | 2013 | 7 Pages |
Abstract
⺠BCPs, the polysaccharides from Bupleurum chinense, impact the recruitment and migration of neutrophils. ⺠BCPs significantly blocks the fMLP chemoattractant receptor-mediated functions, including regulation of affinity and avidity of β2 integrin, actin polymerization, and Vav1 and Rac1 activation. ⺠We provide novel mechanistic insights into the poorly understood signaling network that polysaccharides interfere with the migration of leukocytes to inflammatory sites.
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Authors
Haibin Tong, Dan Tian, Zhongmei He, Yang Liu, Xiaodan Chu, Xin Sun,