Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10602206 | Carbohydrate Polymers | 2012 | 10 Pages |
Abstract
⺠Conjugation of an amino-alkyne moiety to N-phthaloyl chitosan's C6 hydroxyls, after pre-activation with N,Nâ²-carbonyldiimidazole (CDI). ⺠Chemoselective azide-alkyne conjugation between the alkynylated polymer and a commercial PEG-like azide. ⺠Removal of the amine-protecting phthaloyl group to yield back chitosan's original primary amines, responsible for chitosan's bioadhesive and tissue-regenerating properties. ⺠Full characterization of starting, intermediate and final polymers by a toolbox of techniques, including FT-IR, SS-NMR and XPS.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
José Ricardo Oliveira, M. Cristina L. Martins, LuÃs Mafra, Paula Gomes,