Article ID Journal Published Year Pages File Type
10602206 Carbohydrate Polymers 2012 10 Pages PDF
Abstract
► Conjugation of an amino-alkyne moiety to N-phthaloyl chitosan's C6 hydroxyls, after pre-activation with N,N′-carbonyldiimidazole (CDI). ► Chemoselective azide-alkyne conjugation between the alkynylated polymer and a commercial PEG-like azide. ► Removal of the amine-protecting phthaloyl group to yield back chitosan's original primary amines, responsible for chitosan's bioadhesive and tissue-regenerating properties. ► Full characterization of starting, intermediate and final polymers by a toolbox of techniques, including FT-IR, SS-NMR and XPS.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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