Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10602301 | Carbohydrate Polymers | 2012 | 9 Pages |
Abstract
⺠Mixed hydrogels based on natural, biodegradable and biocompatible polysaccharides, such as cellulose (C) and chondroitin sulphate (CS) in various mixing ratios were prepared and tested as carriers for novel NO-donor compounds. ⺠The swelling and release behaviour can be controlled by C/CS composition and morphology. ⺠The 7-[2-nitroxiacetyl-oxy-3-(4-acetyl-amino-phenoxy)-propyl]-8-morpholino-1,3-dimethyl-xanthine nitric oxide donor compound release is significantly prolonged from hydrogels containing a high content of chondroitin sulphate.
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Authors
Ana-Maria Oprea, Lenuta Profire, Catalina Elena Lupusoru, Cristina Mihaela Ghiciuc, Diana Ciolacu, Cornelia Vasile,