| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10602409 | Carbohydrate Polymers | 2011 | 6 Pages |
Abstract
- Heparosan produced from Escherichia coli is a precursor of bioengineered heparin.
- Control of heparosan molecular weight is critical to produce a generic version of heparin.
- Photochemical depolymerization of heparosan using titanium dioxide is possible.
- Controlled depolymerization can afford heparosan of appropriate molecular weight to prepare bioengineered heparin.
- Controlled depolymerization does not alter the structure of the heparosan backbone.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kyohei Higashi, Mellisa Ly, Zhenyu Wang, Sayaka Masuko, Ujjwal Bhaskar, Eric Sterner, Fuming Zhang, Toshihiko Toida, Jonathan S. Dordick, Robert J. Linhardt,