Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10602577 | Carbohydrate Polymers | 2011 | 6 Pages |
Abstract
Two novel polysaccharides, WIPS and AIPS, were isolated and fractionated respectively from hot water and alkaline extracts of the mycelial biomass of a medicinal fungus Cordyceps sinensis (strain Cs-HK1). Through analytical and degradation experiments, WIPS and AIPS were characterized as α-d-glucans with a backbone of (1 â 4)-linked α-d-Glcp (>60%) and very similar molecular weights (Mw: WIPS 1180 kDa; AIPS 1150 kDa). WIPS had a short branch of (1 â 6)-linked α-d-Glcp (â¼14%), but AIPS was a linear glucan, distinctive from the branched structures of most glucans from medicinal fungi. In aqueous alkaline solutions, both AIPS and WIPS exhibited a random coil structure with the similar conformational parameters but significantly different polydispersity indexes, 0.19 versus 0.37. AIPS exhibited much more significant antitumor and immuno-stimulatory effects than WIPS in animal tests on melanoma tumor-bearing mice.
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Authors
Jing-Kun Yan, Wen-Qiang Wang, Lin Li, Jian-Yong Wu,