| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10602618 | Carbohydrate Polymers | 2013 | 10 Pages |
Abstract
⺠Heparosan chain length and the sugar unit backbone composition determine the biological activity of heparin and heparan sulfate. ⺠Different methods used to synthesize heparosan are reviewed. ⺠The use of biocatalysts in vitro is the most promising method to produce defined heparosan polymers. ⺠P. multocida heparosan synthase PmHS2 appears to be the most adequate biocatalyst. ⺠Advancements in the field of the synthesis of bioengineered heparin are also reported.
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Authors
Anaïs A.E. Chavaroche, Lambertus A.M. van den Broek, Gerrit Eggink,