| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10602707 | Carbohydrate Polymers | 2013 | 10 Pages |
Abstract
⺠Stable 5-fluorouracil-loaded chitin nanogel (120-140 nm) was developed. ⺠FCNGs have almost same steady state flux as control 5-FU by skin permeation study. ⺠FCNGs retained in deeper layers of skin as 4-5 times more than 5-FU. ⺠More uptake and higher toxicity on melanoma, sparing the normal fibroblast cells. ⺠Histopathology showed no inflammatory signs by cationically charged FCNGs.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M. Sabitha, N. Sanoj Rejinold, Amrita Nair, Vinoth-Kumar Lakshmanan, Shantikumar V. Nair, R. Jayakumar,