Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10602948 | Carbohydrate Polymers | 2012 | 7 Pages |
Abstract
⺠The thermo-sensitivity of poly(l-lactide)-g-pullulan (PLP) copolymers was investigated. ⺠PLP copolymers form self-organized nanogels consisting of hydrophobic cores of poly(l-lactide) and hydrophilic outer-shells of pullulan in an aqueous environment. ⺠Lactide substitution degree to the pullulan backbone affects the phase-transition temperature of PLP. ⺠The thermoresponsive system release more drug amount with temperature increase, resulting in effectively killing cancer cells.
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Authors
Seogjin Seo, Chung-Sung Lee, Young-Seok Jung, Kun Na,