Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10603521 | Carbohydrate Polymers | 2005 | 6 Pages |
Abstract
A 32 factorial design investigation to optimize N-carboxybutylchitosan was carried out varying the levulinic acid/chitosan molar ratio between 1.00 and 3.00 and the sodium borohydride/chitosan molar ratio from 0.50 to 1.00. 1H NMR spectra signals at 1.0 and 2.5Â ppm were used to monitor the reaction system. A quadratic model having significant terms for both molar ratios was found for N-carboxybutylchitosan substitution degree whereas a linear model best describes the substitution degree of 5-methylpyrrolidinone chitosan. Maximum N-carboxybutylchitosan and minimum 5-methylpyrrolidinone chitosan substitution degrees occur for levulinic acid/chitosan molar ratios between 2.00 and 3.00 and a 0.50 for sodium borohydride/chitosan molar ratio.
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Authors
Kátia S.C.R. dos Santos, Hélio S.R.C. Silva, Elizabeth I. Ferreira, Roy E. Bruns,