| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10603579 | Carbohydrate Polymers | 2013 | 5 Pages |
Abstract
On the basis of previous test that selenizing Chinese angelica polysaccharides (sCAPs) with stronger immune-enhancing activity in vitro were picked out, the immune-enhancing activity in vivo of three sCAPs, sCAP2, sCAP6 and sCAP8, at high and low dosage were compared taking the unmodified Chinese angelica polysaccharide (CAP) as control by determination of peripheral lymphocyte proliferation, serum antibody titer, IFN-γ and IL-6 contents in chicken vaccinated with Newcastle Disease vaccine. The results showed that three sCAPs at suitable dosage could significantly promote lymphocyte proliferation, enhance serum antibody titer, IFN-γ and IL-6 contents as compared with unmodified CAP, sCAP2 at low dosage possessed the strongest action. These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of CAP, sCAP2 possessed the best efficacy and would be as a component drug of new-type immunoenhancer.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tao Qin, Jin Chen, Deyun Wang, Yuanliang Hu, Jing Zhang, Mi Wang, Shulei Qiu, Zhenzhen Gao, Rongrong liu, Yun Yu, Yee Huang, Qiaochu Wang, Qiaoxiu Wang,