| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10604000 | Carbohydrate Polymers | 2012 | 17 Pages |
Abstract
⺠Injection of hyaluronan in damaged joints normalizes endogenous hyaluronan synthesis. ⺠Synergic performances of chitosan + hyaluronan lead to hyaline cartilage generation. ⺠Chitosan cryogels help chondrocytes propagate and assume the convenient phenotype. ⺠Chitosan favors typical ECM, collagen-II and GAG formation in the new cartilage. ⺠Chitosan induces the chondrogenic differentiation of mesenchymal stem cells.
Keywords
MSCTGF-βATDC5pEGFPPNIPAMN-hydroxysuccinimideN/PRTPCRNHSGAGPGE2FGFDPBSECMPLGAMMPIL1TNFαSox9EDCOsteoarthritisinterleukin 1Transforming Growth Factor Betatumor necrosis factor alphaDegree of deacetylationdegree of acetylationStem cellsCartilageGrowth factorsfibroblast growth factorDulbecco's phosphate-buffered salineExtracellular matrixmatrix metalloproteinase(s)BMPAverage molecular weightHyaluronanReal time polymerase chain reactionBone morphogenetic proteinProstaglandin E2Poly(N-isopropylacrylamide)poly(lactide-co-glycolide)ChondrocyteChondroitinChitosanglycosaminoglycan(s)
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Riccardo A.A. Muzzarelli, Francesco Greco, Alberto Busilacchi, Vincenzo Sollazzo, Antonio Gigante,