Bi- and trivalent glycopeptide mannopyranosides as inhibitors of type 1 fimbriae-mediated bacterial adhesion: variation of valency, aglycon and scaffolding

Article ID	Journal	Published Year	Pages	File Type
10605622	Carbohydrate Research	2011	8 Pages	PDF

Abstract

Mannopyranoside ligands for the bacterial lectin FimH with diverse aglycon moieties can be scaffolded on small peptides in order to vary the valency of the resulting glycopeptides, and the spatial arrangement of the ligated saccharides.

Keywords

DPR GFP Mannopyranosides ALA L-lysine l-Glycine FMOC l-Serine l-Alanine SER fluorenylmethoxycarbonyl LYS DIPEA Type 1 fimbriae HATU green fluorescent protein Bacterial adhesion Gly Glycopeptides