1-Deoxy-d-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines

► N-Alkylation of 1-deoxy-D-galactonojirimycin with dansylamino terminated spacer arms provides powerful inhibitors. ► These enhance mutant lysosomal -galactosidase activities in GM1 gangliosidosis cell lines. ► Based on their fluorescence, they can serve as selective intracellular organellar probes.