Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10606582 | Carbohydrate Research | 2011 | 10 Pages |
Abstract
d-Glucuronate and l-iduronate-containing disaccharides related to the antithrombin-binding domain of heparin were prepared. The carboxylic function of the uronic acid unit was formed on a disaccharide level in the case of the glucuronate, while on a monosaccharide level in the case of the iduronate derivatives. Synthesis of their sulfonic acid analogues was carried out analoguosly applying sulfonatomethyl-containing acceptors in the form of either salts or methyl esters. Significant difference could be observed in the methyl ether formation reactions of the sulfonatomethyl-containing uronate disaccharides and the non-sulfonic acid uronates.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mihály Herczeg, László Lázár, Attila Mándi, Anikó Borbás, István Komáromi, András Lipták, Sándor Antus,