| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10606593 | Carbohydrate Research | 2011 | 7 Pages |
Abstract
Macromolecular conjugates of a natural polysaccharide, hyaluronic acid, with diethylenetriaminepentaacetic acid (DTPA)-metal complexes were synthesized and characterized by FTIR, NMR, SEC-MALLS and ICP analysis. Several parameters of the cross-linking reaction as molecular weight of starting HA, temperature, equivalent of DTPA bis-anhydride, concentration of HA, presence of transacylation catalyst DMAP and reaction time were studied. The mechanism for the reaction was suggested and relationship between the molecular weight assigned by SEC-MALLS, reaction parameters and rheological properties of the final cross-linked products were investigated.
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Authors
Radovan Buffa, JiÅà BÄÅ¥ák, Sofiane Kettou, Martina Hermannová, Lucie PospÃÅ¡ilová, VladimÃr Velebný,