Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10609196 | European Polymer Journal | 2011 | 7 Pages |
Abstract
Block copolypeptides with their inherent nanometer length scale of phase separation, provide means of manipulating the type (α-helices, β-strands) and persistence of peptide secondary structures. Two such examples are employed based on the α-helical poly(γ-benzyl-l-glutamate) (PBLG) polypeptide as one block and poly(l-leucine) (α-helical) or poly(O-benzyl-l-tyrosine) (POBT) (β-strands) as the second block. Although both secondary structures are present in the copolypeptides the effect of nano-scale confinement is to induce folding in the POBT β-sheets and to maintain the defected α-helices of PBLG and PLEU with a limited lateral coherence.
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Organic Chemistry
Authors
M. Mondeshki, H.W. Spiess, T. Aliferis, H. Iatrou, N. Hadjichristidis, G. Floudas,