| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10609769 | European Polymer Journal | 2013 | 11 Pages |
Abstract
Well-defined amphiphilic block copolymers composed of hydrophilic and hydrophobic blocks linked through an acid-labile acetal bond were synthesized directly by RAFT polymerization. Potential use of the pH-labile shedding behavior of the copolymers was demonstrated by conjugating a thiol-modified siRNA to Ï-pyridyldisulfide modified poly(ethylene glycol)-b-poly(cholesteryl methacrylate) (PEG-b-PCMA). The resultant triblock polymer, PEG-b-PCMA-b-siRNA proved to release PCMA-b-siRNA and siRNA in acidic and reductive conditions, respectively.
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Authors
Xin Huang, Sema Ilknur Sevimli, Volga Bulmus,