| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10613369 | Journal of Controlled Release | 2005 | 6 Pages |
Abstract
We devised a simple method for incorporating drugs into solid calcium carbonate nanoparticles (nano-CaCO3). The size of nano-CaCO3 was controlled by mixing speed. Washing the nanoparticles released little incorporated drug but much drug that was adsorbed on the surface. In an in vitro releasing test, granulocyte colony-stimulating factor incorporated in nano-CaCO3 was chemically stable and released very slowly. Subcutaneous injection of nano-CaCO3 incorporating betamethasone phosphate (BP) resulted in a smaller initial increase in plasma concentration and a subsequent sustained release in compared with betamethasone phosphate solution. Nano-CaCO3 may be useful to deliver hydrophilic drugs and bioactive proteins.
Related Topics
Physical Sciences and Engineering
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Biomaterials
Authors
Y. Ueno, H. Futagawa, Y. Takagi, A. Ueno, Y. Mizushima,