Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10613458 | Journal of Controlled Release | 2005 | 9 Pages |
Abstract
Tuning the release rates of drugs was accomplished with miscible polymer blends. Dexamethasone (DX) was formulated in a miscible polymer blend composed of two poly(ether urethane)s, one in which DX diffuses relatively quickly and the other in which DX diffuses relatively slowly. Matrices that provide drug diffusion coefficients from 7Ã10â13 to 3Ã10â19 cm2/s were obtained by adjusting the blend ratio. Tunable diffusion coefficients were also achieved with partially miscible blends, such as poly(vinyl acetate) (PVAC)/cellulose acetate butyrate (CAB). However, similar tunable diffusion was not observed with an immiscible polymer blend composed of poly(carbonate urethane) (PCU) and polysulfone (PSF).
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Authors
Su-Ping Lyu, Randall Sparer, Christopher Hobot, Kiem Dang,