Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10613534 | Journal of Controlled Release | 2005 | 11 Pages |
Abstract
The results showed that matrix properties depended significantly on both relative amount of poloxamer and chitosan salt type. The rank orders of chitosan salts for the four processes evaluated were as follows: drug release: chitosan acetate>chitosan citrate>chitosan lactate; swelling: chitosan lactate>chitosan acetate=chitosan citrate; erosion: chitosan citrate>chitosan lactate>chitosan acetate; mucoadhesion: chitosan lactate>chitosan acetate=chitosan citrate. Mucoadhesion was particularly favoured when poloxamer 407 was present at about 30% (w/w). The matrix composed of chitosan lactate and poloxamer 407 showed the best characteristics for buccal administration.
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
S. Cafaggi, R. Leardi, B. Parodi, G. Caviglioli, E. Russo, G. Bignardi,