| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10613557 | Journal of Controlled Release | 2005 | 9 Pages |
Abstract
These results suggest that electroporation decreases the electroosmosis produced by iontophoresis, and that electroporation increases skin permeability to neutral low and high model compounds (mannitol and dextran rhodamine B) probably due to an enlarged permeation pathway. Thus, electroporation affects osmotic flow from the anode to cathode during iontophoresis. Therefore, one has to pay attention to the change in electroosmosis produced by iontophoresis for the combined use of electroporation and iontophoresis to attain a high skin-penetration enhancing effect.
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Seiji Tokumoto, Kenji Mori, Naruhito Higo, Kenji Sugibayashi,