Prognostic factors in desmoid-type fibromatosis: a clinicopathological and immunohistochemical analysis of 46 cases

SummaryAimsTo determine risk factors for recurrence of desmoidtype fibromatosis (aggressive fibromatosis).MethodsForty-six cases of desmoid-type fibromatosis in Taiwanese patients were analysed for an association between tumour recurrence and clinical features, pathology, and the presence of p53 protein and β-catenin on immunohistochemical staining.ResultsSix (13%) of 46 patients developed recurrence after surgical resection. The only factor significantly associated with tumour recurrence was positive surgical margin (p = 0.035).ConclusionsA positive surgical margin is a risk factor for recurrence of desmoid-type fibromatosis.