| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10625653 | Ceramics International | 2014 | 35 Pages |
Abstract
Overall, we have determined Pt-Fe-HAP could be prepared by a co-precipitation method with Fe2+/Pt2+ incorporation. The platinum and iron contents were 3.69 wt% and 12.20 wt%, respectively. The hysteresis curves showed that the Pt-Fe-HAP possessed ferromagnetic properties at low magnetic fields. The water temperature could be raised to 46 °C when the Pt-Fe-HAP suspension was treated in a magnetic field for 6 min. We also confirmed that the extraction solution of Pt-Fe-HAP was nontoxic, but the direct culture of 3T3 cells with these nanoparticles was harmful. Finally, the results of the LDH assay revealed Pt-Fe-HAP was highly toxic to A549 cells after magnetic field treatment under hyperthermia but no damage to fibroblast cells was observed. The magnetic Pt-Fe-HAP nanoparticles show the potential to be a dual agent to treat cancer cells by chemo-hyperthermia therapy.
Related Topics
Physical Sciences and Engineering
Materials Science
Ceramics and Composites
Authors
Ching-Li Tseng, Kuo-Chi Chang, Mei-Chun Yeh, Kai-Chiang Yang, Tzu-Piao Tang, Feng-Huei Lin,