Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10674933 | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms | 2005 | 12 Pages |
Abstract
The long-living radioisotope 41Ca could overcome current limitations in assessing the impact of interventions on bone health in controlled human studies. Changes in bone Ca metabolism can be identified directly via the induced changes in 41Ca excretion from 41Ca-labelled bones via the n(41Ca)/n(40Ca) ratio in urine. A 41Ca dose material (IRMM-3703), for use in human studies, was produced by IRMM within the EC funded project OSTEODIET. The 41Ca base material was purified and the purified solution is certified for both isotopic composition and amount content by isotope dilution mass spectrometry. The 44Ca-enriched isotope reference material, IM-6009, was used as spike and the natural Ca reference material, IM-6008, was used for correction of procedural bias. Isotope ratio measurements were performed using thermal ionisation mass spectrometry (TIMS). The certified n(41Ca)/n(40Ca) ratio in IRMM-3703 is 0.012789 (58). A set of synthetic isotope mixtures, IRMM-3701, was prepared from IRMM-3703. It enables comparability of 41Ca measurement results in different laboratories and by different techniques. The IRMM-3701 series is derived from gravimetric mixing of IRMM-3703 and a Ca solution of natural isotopic composition. It covers n(41Ca)/n(40Ca) ratios in the range of 1.0114(68)Â ÃÂ 10â6 to 1.0524(71)Â ÃÂ 10â13.
Keywords
Related Topics
Physical Sciences and Engineering
Materials Science
Surfaces, Coatings and Films
Authors
Carmel Hennessy, Michael Berglund, Markus Ostermann, Thomas Walczyk, Hans-Arno Synal, Christopher Geppert, Klaus Wendt, Philip D.P. Taylor,