Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10691028 | Ultrasound in Medicine & Biology | 2016 | 10 Pages |
Abstract
Apparent integrated backscatter (AIB) is a common ultrasound parameter used to assess cartilage matrix degeneration. However, the specific contributions of chondrocytes, proteoglycan and collagen to AIB remain unknown. To reveal these relationships, this work examined biopsies and cross sections of human, ovine and bovine cartilage with 40-MHz ultrasound biomicroscopy. Site-matched estimates of collagen concentration, proteoglycan concentration, collagen orientation and cell number density were employed in quasi-least-squares linear regression analyses to model AIB. A positive correlation (R2 = 0.51, p < 10â4) between AIB and a combination model of cell number density and collagen concentration was obtained for collagen orientations approximately perpendicular (>70°) to the sound beam direction. These findings indicate causal relationships between AIB and cartilage structural parameters and could aid in more sophisticated future interpretations of ultrasound backscatter.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Acoustics and Ultrasonics
Authors
Nils Männicke, Martin Schöne, Jukka Liukkonen, Dominik Fachet, Satu Inkinen, Markus K. Malo, Michael L. Oelze, Juha Töyräs, Jukka S. Jurvelin, Kay Raum,