Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10691297 | Ultrasound in Medicine & Biology | 2015 | 9 Pages |
Abstract
This prospective study aimed to elucidate the effect of phase-related quantitative parameters of contrast-enhanced ultrasound (CEUS) with perflubutane microbubble agent to assess the cellular differentiation of hepatocellular carcinoma (HCC). Intensity was analyzed in 94 lesions (19.4 ± 4.9 mm, 86 patients), 47 well-differentiated HCCs (wHCCs) and 47 moderately-differentiated HCCs (mHCCs): Ie (early phase) = Ite (tumor) â Ile (liver), Ip (post-vascular phase) = Itp (tumor) â Ilp (liver), Iep = Ie â Ip. The area under the receiver operating characteristic curve with the best cutoff value (Ie, 13.2, Ip, â4.5, Iep, 21.3) for discriminating between wHCC and mHCC was 0.6922 for Ie, 0.7680 for Ip and 0.7925 for Iep, which indicated a significantly greater ability to differentiate between wHCC and mHCC compared with visual/qualitative assessment (early phase, 0.6170, p = 0.04; post-vascular phase, 0.6702, p = 0.01; both phases, 0.7021, p = 0.04). In conclusion, Iep was found to have the highest diagnostic ability, suggesting it is a promising parameter for the cellular differentiation of HCCs with CEUS.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
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Authors
Takayuki Kondo, Hitoshi Maruyama, Soichiro Kiyono, Tadashi Sekimoto, Taro Shimada, Masanori Takahashi, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Akinobu Tawada, Tetsuhiro Chiba, Fumihiko Kanai, Osamu Yokosuka,