Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10691702 | Ultrasound in Medicine & Biology | 2014 | 10 Pages |
Abstract
The accumulation of fat droplets within the liver is an important marker of liver disease. This study assesses gradations of steatosis in mouse livers using crawling waves, which are interfering patterns of shear waves introduced into the liver by external sources. The crawling waves are detected by Doppler ultrasound imaging techniques, and these are analyzed to estimate the shear wave speed as a function of frequency between 200 and 360Â Hz. In a study of 70 mice with progressive increases in steatosis from 0% to >60%, increases in steatosis are found to increase the dispersion, or frequency dependence, of shear wave speed. This finding confirms an earlier, smaller study and points to the potential of a scoring system for steatosis based on shear wave dispersion.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Acoustics and Ultrasonics
Authors
Christopher T. Barry, Zaegyoo Hah, Alexander Partin, Robert A. Mooney, Kuang-Hsiang Chuang, Alicia Augustine, Anthony Almudevar, Wenqing Cao, Deborah J. Rubens, Kevin J. Parker,