Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10691900 | Ultrasound in Medicine & Biology | 2013 | 9 Pages |
Abstract
Ultrasound bio-microscopy was used to measure hemodynamic changes in the left main coronary artery after myocardial infarction (MI), and its usefulness in estimating infarct size was evaluated. MI was induced by left anterior descending artery ligation. Diastolic peak velocity (Vd), mean flow velocity (Vmean) and the velocity-time integral (VTI) were measured 2 and 6 h after MI. Serum troponin I levels were assayed 2, 6 and 12 h after MI. At 2 h, Vmean and VTI significantly differed between mice that underwent low and high left anterior descending artery ligation; Vd, Vmean and VTI were correlated with infarct size (r = â0.557, â0.693 and â0.672, respectively; all p < 0.01). Infarct size was more strongly correlated with 2-h ultrasound bio-microscopy measurements than with 2-h serum troponin I level. Measurement of coronary artery blood flow by ultrasound bio-microscopy may be useful for early estimation of infarct size in mice.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Acoustics and Ultrasonics
Authors
Rui-Juan Su, Jun-Meng Zhang, Rong-Juan Li, Yan Sun, Bo Jiang, Ning Ma, Zhi-An Li, Xiang-Hong Luo, Li Song, Jing-Li Xue, Zheng Wang, Ya Yang,