Radial Anatomic Variation of Ultrasonic Velocity in Human Cortical Bone

Quantitative ultrasound techniques can be used to retrieve cortical bone quality. The aim of this study was to investigate the anatomic variations in speed of sound (SOS) in the radial direction of cortical bone tissue. SOS measurements were realized in 17 human cortical bone samples with a 3.5-MHz transverse transmission device. The radial dependence of SOS was investigated in a direction perpendicular to the periosteum. For each sample, bone porosity was measured using an X-ray micro-computed tomography device. The mean SOS was 3586 ± 255 m/s. For 16 of 17 specimens, similar radial variations in SOS were observed. In the periosteal region, SOS first decreased in the direction of the endosteum and reached a minimum value approximately in the middle of the cortical bone. SOS then increased, moving to the endosteal region. A significant negative correlation was obtained between SOS and porosity (R = -0.54, p = 0.02).