Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10692023 | Ultrasound in Medicine & Biology | 2014 | 14 Pages |
Abstract
The aim of this study was to investigate experimental conditions for efficient and controlled in vivo liver tissue ablation by magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) in a swine model, with the ultimate goal of improving clinical treatment outcome. Histological changes were examined both acutely (four animals) and 1 wk after treatment (five animals). Effects of acoustic power and multiple sonication cycles were investigated. There was good correlation between target size and observed ablation size by thermal dose calculation, post-procedural MR imaging and histopathology, when temperature at the focal point was kept below 90°C. Structural histopathology investigations revealed tissue thermal fixation in ablated regions. In the presence of cavitation, mechanical tissue destruction occurred, resulting in an ablation larger than the target. Complete extra-corporeal MR-guided HIFU ablation in the liver is feasible using high acoustic power. Nearby large vessels were preserved, which makes MR-guided HIFU promising for the ablation of liver tumors adjacent to large veins.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Acoustics and Ultrasonics
Authors
Frédéric Courivaud, Airazat M. Kazaryan, Alice Lund, Vivian C. Orszagh, Aud Svindland, Irina Pavlik Marangos, Per Steinar Halvorsen, Peter Jebsen, Erik Fosse, Per Kristian Hol, Bjørn Edwin,