| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10710453 | Journal of Magnetism and Magnetic Materials | 2005 | 8 Pages |
Abstract
A new generation of susceptibility contrast agents for MRI and based on maghemite cores covalently bonded to dextran stabilizing macromolecules was investigated. The multistep preparation of these versatile ultrasmall superparamagnetic iron oxides (VUSPIO) consisted of colloidal maghemite synthesis, surface modification by aminopropylsilane groups, and coupling of partially oxidized dextran via Schiff's bases and secondary amine bonds. The dextran corona might be easily derivatized, e.g. by PEGylation.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Stéphane Mornet, Josik Portier, Etienne Duguet,