Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10710495 | Journal of Magnetism and Magnetic Materials | 2005 | 5 Pages |
Abstract
Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Christoph Alexiou, Roland Jurgons, Roswitha Schmid, Andrea Hilpert, Christian Bergemann, Fritz Parak, Heinrich Iro,