Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10710498 | Journal of Magnetism and Magnetic Materials | 2005 | 7 Pages |
Abstract
A paradigm for brain cancer detection, treatment, and monitoring is established. Multifunctional biomedical nanoparticles (30-60Â nm) containing photosensitizer externally deliver reactive oxygen species (ROS) to cancer cells while simultaneously enhancing magnetic resonance imaging (MRI) contrast providing real-time tumor kill measurement. Plasma residence time control and specific cell targeting are achieved. A 5Â min treatment in rats halted and even reversed in vivo tumor growth after 3-4 days post-treatment.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Raoul Kopelman, Yong-Eun Lee Koo, Martin Philbert, Bradford A. Moffat, G. Ramachandra Reddy, Patrick McConville, Daniel E. Hall, Thomas L. Chenevert, Mahaveer Swaroop Bhojani, Sarah M. Buck, Alnawaz Rehemtulla, Brian D. Ross,