Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10710500 | Journal of Magnetism and Magnetic Materials | 2005 | 14 Pages |
Abstract
A superparamagnetic iron oxide nanoparticle, coated with polyvinyl alcohol, (PVA-SPION) and its fluorescently functionalized analogue (amino-PVA-Cy3.5-SPION) were compared in vivo as proof of principle for future use in magnetic drug targeting in inflammatory joint diseases. They were injected either intraarticularly or periarticularly and their uptake by cells of the synovial membrane was evaluated. Uptake was completed in 48Â h and was enforced by an extracorporally applied magnet.
Keywords
Related Topics
Physical Sciences and Engineering
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Condensed Matter Physics
Authors
Katja Schulze, Annette Koch, Bernhard Schöpf, Alke Petri, Benedikt Steitz, Mathieu Chastellain, Margarethe Hofmann, Heinrich Hofmann, Brigitte von Rechenberg,