| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10710506 | Journal of Magnetism and Magnetic Materials | 2005 | 9 Pages |
Abstract
Two specific binding sites for doxorubicin were revealed at the plasma membrane of human erythrocytes on investigation of the binding of doxorubicin magnetic nanoconjugates. Free and conjugated doxorubicins modulated signal transduction in erythrocytes in a similar way. Both up-regulated nitric oxide and cyclic GMP (cGMP) and down-regulated cyclic AMP (cAMP) production and stabilize the membranes of damaged erythrocytes.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Olga Mykhaylyk, Anatoliy Kotzuruba, Nataliya Dudchenko, Gyula Törok,