Doxorubicin magnetic conjugate targeting upon intravenous injection into mice: High gradient magnetic field inhibits the clearance of nanoparticles from the blood

The efficiency of a stationary magnetic field (|∇B|=200mT/cm) in increasing the bioavailability of a doxorubicin-magnetite nanoparticle conjugate (diameter of 24±19 nm) in the mouse lung was determined by pharmacokinetic investigation using electron spin resonance (ESR). The magnetic field was also found to inhibit the elimination of nanoparticles from the blood and increase the conjugate half-life and bioavailability in the blood.