| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10729691 | Applied Radiation and Isotopes | 2012 | 10 Pages |
Abstract
⺠Four 18F-labeled radioligands were synthesized and evaluated as SERT imaging agents. ⺠4-[18F]F-ADAM and [18F]F-AFM had high specific uptake in SERT-rich brain regions. ⺠2-[18F]F-ADAM and N-Desmethyl-4-[18F]F-ADAM had low specific uptake in brain. ⺠4-[18F]F-ADAM may be the most appropriate SERT imaging agent for human studies.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
![Synthesis and comparison of 4-[18F]F-ADAM, 2-[18F]F-ADAM, N-Desmethyl-4-[18F]F-ADAM and [18F]F-AFM as serotonin transporter imaging agents](/preview/png/10729691.png "First Page Preview: Synthesis and comparison of 4-[18F]F-ADAM, 2-[18F]F-ADAM, N-Desmethyl-4-[18F]F-ADAM and [18F]F-AFM as serotonin transporter imaging agents")
Authors
Ya-Yao Huang, Wen-Sheng Huang, Kuo-Hsing Ma, Ta-Kai Chou, Yu-Yeh Kuo, Cheng-Yi Cheng, Chyng-Yann Shiue,